Brush Creek is a stream in southern Laclede County in the U.S. state of Missouri. It is a tributary of the Osage Fork Gasconade River.
The stream headwaters arise about one mile northeast of Phillipsburg adjacent to I-44 at . The stream flows southeast under I-44 and then generally east passing under Missouri Route C and then route PP north of Morgan. It continues east to its confluence with the Osage Fork about 1.5 miles west of Missouri Route 5 at .
Brush Creek was named for the thick brush lining its course.