Bruffey Creek (also Bruffey's Creek) is a stream in Pocahontas County in the U.S. state of West Virginia. The nearest town is Lobelia, West Virginia.
The creek's sink joins the Hills Creek sink to form the Hills-Bruffey cave system.
Bruffey Creek has the name of Patrick Bruffey, an early settler.
In 1910, Bruffey's Creek School, a two-room school, was constructed on the creek bank. It closed in 1935 and was demolished in the early 1940s.