Brixey Creek (also spelled Brixy Creek) is a stream in Ozark County, Missouri. It is a tributary of Spring Creek. The headwaters of Brixey Creek are southwest of the community of Brixey. The stream flows to the northeast past Brixey and parallels Missouri Route N passing under Route N and Missouri Route 95 just south and east of their intersection. The stream flows north parallel to Route N to its confluence with Spring Creek just east of Rockbridge.
Brixey Creek has the name of the local family.