Brinker Run is a long 2nd order tributary to Sewickley Creek in Westmoreland County, Pennsylvania.
Brinker Run rises about 0.25 miles northwest of Humphreys, Pennsylvania, and then flows southwest to join Sewickley Creek at United.
Brinker Run drains of area, receives about 42.9 in/year of precipitation, has a wetness index of 367.95, and is about 43% forested.