Bolshoye Zaymishche () is a rural locality (a village) in Pertsevskoye Rural Settlement, Gryazovetsky District, Vologda Oblast, Russia. The population was 30 as of 2002.
Bolshoye Zaymishche is located northeast of Gryazovets (the district's administrative centre) by road. Yezhovo is the nearest rural locality.