Bolshoye Sirino () is a rural locality (a village) in Yenangskoye Rural Settlement, Kichmengsko-Gorodetsky District, Vologda Oblast, Russia. The population was 48 as of 2002.
Bolshoye Sirino is located 43 km southeast of Kichmengsky Gorodok (the district's administrative centre) by road. Shelomets is the nearest rural locality.