Bolshoye Kalikino () is a rural locality (a village) in Nizhneyerogodskoye Rural Settlement, Velikoustyugsky District, Vologda Oblast, Russia. The population was 5 as of 2002.
Bolshoye Kalikino is located 34 km southwest of Veliky Ustyug (the district's administrative centre) by road. Krasavino is the nearest rural locality.