Bolshoye Denisyevo () is a rural locality (a village) in Komyanskoye Rural Settlement, Gryazovetsky District, Vologda Oblast, Russia. The population was 3 as of 2002.
Bolshoye Denisyevo is by road north of Gryazovets (the district's administrative centre). Maloye Denisyevo is the nearest rural locality.