Bolshaya Sinega () is a rural locality (a village) in Krasavinskoye Rural Settlement, Velikoustyugsky District, Vologda Oblast, Russia. The population was 45 as of 2002.
Bolshaya Sinega is located 23 km northeast of Veliky Ustyug (the district's administrative centre) by road. Vasilyevskoye is the nearest rural locality.