Bollène (; Provençal: Bouleno) is a commune in the Vaucluse department in the Provence-Alpes-Côte d'Azur region in southeastern France.
Bollène is a commune located in the north of the Vaucluse department next to the junction of Drôme, Ardèche and Gard departments. Located near major communication routes, the city (old town) occupies the northern end of a sandstone plateau where lie the communes of Mondragon, Mornas, Uchaux and Lagarde-Paréol. The rest of the town, including the lower town, stretches over a fertile plain which rests on a large layer of clay.
Bollène is twinned with L'Alcúdia, Spain, since 1994.