Bobo is a census-designated place and unincorporated community in Coahoma County, Mississippi, United States. Bobo is located on U.S. routes 61 and 278, southwest of Clarksdale.
It was first named as a CDP in the 2020 Census which listed a population of 118.
Bobo was named for world-champion bear hunter Robert E. Bobo. Bobo is located on the former Yazoo and Mississippi Valley Railroad and was once home to six general stores, a grocery store, and two sawmills. A post office operated under the name Bobo from 1886 to 1973.