Blepharis mitrata is a species of plant in the family Acanthaceae. It a subshrub native to deserts and dry shrublands in Namibia and the Cape Provinces and Free State of South Africa, including the Khomas Honchland. It is threatened by habitat loss. The whole plant is very spiny.
The fruits, seeds and roots of Blepharis mitrata are claimed to be useful for hemorrhoids, cough, wounds and fontanel hardening, though further analysis is needed to determine its true medical value.