The Blake baronetcy, of Twizell Castle in the County of Durham, was created in the Baronetage of Great Britain on 25 May 1774 for Francis Blake, a collateral descendant of the 1st Baronet of the first creation. He inherited, with other property, the ruined Twizell Castle.
The 3rd Baronet sat as Member of Parliament for Berwick-upon-Tweed. The title became extinct on his death in 1860.