BioNumerics is a bioinformatics desktop software application that manages microbiological data. It is developed by Applied Maths NV, a bioMérieux company.
BioNumerics was first released in 1998. PulseNet, a network run by the Centers for Disease Control and Prevention (CDC), uses BioNumerics to compare pulsed field gel electrophoresis (PFGE) patterns and whole genome sequences from different bacterial strains. CaliciNet, an outbreak surveillance network for noroviruses, is another example of a network which uses BioNumerics to submit norovirus sequences and basic epidemiologic information to a central database. ÃÂ
The basis of BioNumerics is a database consisting ofâ¯entries. Theâ¯entries correspond to the individual organisms or samples under studyâ¯andâ¯areâ¯characterizedâ¯by a uniqueâ¯keyâ¯and by a number of user-defined information fields. Each entry in a databaseâ¯may be characterizedâ¯by one or moreâ¯experimentsâ¯that can be linked easily to the entry. Inâ¯BioNumerics, experimentsâ¯are dividedâ¯in seven classes:⯠fingerprints,â¯spectra,â¯characters,â¯sequences,â¯sequence read sets,â¯trend data andâ¯matrices.
Examples of BioNumerics applications are whole genome Multi Locus Sequence Typing (wgMLST), whole genome Single Nucleotide Polymorphisms (wgSNP), genome comparison, identification based on MALDI-TOF Mass Spectrometry, PFGE typing, Amplified Fragment Length Polymorphism (AFLP) typing, sequence-based typing of viruses, antibiotic resistance profiling and functional genotyping.