William Sandifer III (born February 21, 1945) is an American politician. He was a member of the South Carolina House of Representatives from the 2nd District, serving from 1995 to 2024. He is a member of the Republican party.
Sandifer served as Chair of the House Labor, Commerce and Industry Committee.
See also: , , , 2024 South Carolina House of Representatives election
In March 2024, Sandifer filed for re-election. In the 2024 SC Republican primary, he was beaten by Adam Lewis Duncan.