Big Sandy Regional Airport (, former FAA LID: K22) is a public use airport in southwest Martin County, Kentucky. The airport is northeast of Prestonsburg, a city in Floyd County.
The airport covers at an elevation of . Its single runway, 3/21, is .
In the year ending July 12, 2022, the airport had 7,580 aircraft operations, average 21 per day: 85% general aviation, 12% air taxi and 3% military. 17 aircraft were then based at the airport: 14 single-engine, 1 jet, 1 helicopter, and 1 glider.