Men's 12.5 km biathlon events at the 2006 Winter Paralympics were contested at Pragelato on 11 March.
There were three events, and standings were determined by applying a disability factor to the actual times achieved. Additionally, for each missed shot, a penalty of one minute was added to the calculated time.
The visually impaired event was won by Vitaliy Lukyanenko, representing .
The sitting event was won by Vladimir Kiselev, representing .
The standing event was won by Rustam Garifoullin, representing .