Berne-Knox-Westerlo Junior-Senior High School is a public high school located in Berne, Albany County, New York, U.S.A., and is the only high school operated by the Berne-Knox-Westerlo Central School District.
In March 2025, Berne-Knox-Westerlo's varsity boys' basketball team concluded an undefeated season by winning the NYSPHSAA championship.