Baseball was contested at the 1946 Central American and Caribbean Games in Barranquilla, Colombia.
Nine countries participated. The number of athletes a nation entered is in parentheses beside the name of the country.
Venezuela was pegged as the favorite to win the tournament, given the country's recent victories in the 1944 and 1945 Amateur World Series. However, the country was missing most of its 1945 championship-winning team, which had since turned professional with the establishment of the Venezuelan Professional Baseball League.
Willy Miranda, a future Major League Baseball with the New York Yankees and Baltimore Orioles, made his debut with the Cuba national team in the 1946 Games, hitting .250.
The group stage featured a round robin format to determine the medal winners, similar to the format of the 1938 tournament.
Colombia and the Dominican Republic, which both defeated Cuba in the tie-breaker, tied in a thirteen-inning pitcher's duel on December 26. A rematch, which would decide the baseball champion at the tournament, was scheduled for December 28, after the closing ceremonies. However, the Dominican team did not appear, because their return flight had already been booked for the evening of the 28th. Thus, the games committee pronounced Colombia the winners of the tournament.
<nowiki>*</nowiki> Minimum 15 innings pitched<br>