The mayor of Santa Maria () is the highest decision-maker and chief executive of the municipality of Santa Maria, Bulacan, Philippines. He leads the enforcement of municipal ordinances and improvement of public services. The mayor has a term of office of three years, but has a maximum electoral tenure of three consecutive terms. Inaugural holder of the office was Maximo Evidente (1899-1900).
The present 1987 Constitution of the Philippines defined the position, powers and responsibilities of the mayor as well as the municipal charter.
There were 82 capitanes who served the Spanish colonial administration from 1793 to 1899; 12 Presidentes from 1899 to 1937; 4 Alcaldes from 1938 to 1947 and 11 Mayors under various terms and succession from 1947 to present.