Barrs Run is a 2nd order tributary to Tenmile Creek, in Washington County, Pennsylvania.
Barrs Run rises about 0.25 miles east of Marianna, Pennsylvania. It then flows northeast to join Tenmile Creek at Old Zollarsville.
Barrs Run drains of area, receives about 40.6 in/year of precipitation, has a wetness index of 310.46 and is about 66% forested.