Barleria popovii is a species of plant in the family Acanthaceae. It is endemic to the island of Socotra in Yemen. It is an attractive shrub or small tree, with large white night-flowering flowers. It is a rare plant native to the central Hajhir Mountains, where it grows in sheltered submontane woodland from 600 to 750 meters elevation. It has a small but stable population, and the IUCN Red List assesses the species as Endangered.
The species was first described by Bernard Verdcourt in 1966.