Barker House is a historic home located near Henderson, Vance County, North Carolina. It was built about 1764, with an addition built about 1774. It is a -story, five-bay, single pile, heavy timber frame dwelling. The interior has a hall-parlor plan. It was renovated in 2014, with a rebuilt full-width engaged front porch.
It was listed on the National Register of Historic Places in 2014.