Aysha (, , ) is a town in Ethiopia. It is situated about () south of the border with Djibouti and () west of the border with Somaliland. Located in the Sitti Zone in the Somali Region. This town served by a station on the Addis Ababa - Djibouti Railway.
Nearby towns and villages include Hadhagaala (), Dewele (), Guelile (), Ali Sabieh () and Dire Dawa ().
The Aysha massacre was a massacre of ethnic Issa Somalis by Ethiopian army on 13 August 1960 in Aysha, Ethiopia. The Ethiopian troops had descended on the area reportedly to help defuse clan-related conflict. However, according to eye-witness testimony, that Somali men were then taken to a different location and then executed by Ethiopian soldiers. Among the latter, those who fled to Dikhil and Ali Sabieh in Djibouti.
Aysha has a hot desert climate (BWh) in Köppen-Geiger system.