Ayer Hall is a historic building on the campus of Jackson State University. It was the first academic building for what was established as Natchez Seminary after it moved to Jackson, Mississippi and became Jackson College. It is named for donor Charles Ayer. It is listed on the National Register of Historic Places. It was designated a Mississippi Landmark in 1986.
It was built in 1903. A short video tribute was made about it. In 1940, Jackson College was acquired by the state of Mississippi and became Jackson State University.