Atrolysin E (, Crotalus atrox metalloendopeptidase e, hemorrhagic toxin e) is an enzyme. This enzyme catalyses the following chemical reaction
Cleavage of Asn<sup>3</sup>-Gln, Ser<sup>9</sup>-His and Ala<sup>14</sup>-Leu bonds in insulin B chain and Tyr<sup>14</sup>-Gln and Thr<sup>8</sup>-Ser in A chain. Cleaves type IV collagen at Ala<sup>73</sup>-Gln in alpha1(IV) and at Gly<sup>7</sup>-Leu in alpha2(IV)
This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).
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