Astrothelium trypethelioides is a species of corticolous (bark-dwelling) lichen in the family Trypetheliaceae. Found in Venezuela, it was formally described as a new species in 2016 by André Aptroot. The type specimen was collected by Harrie Sipman along the Carapo River (, Bolivar) at an altitude of . The lichen has a smooth, somewhat shiny, pale yellowish-grey thallus that covers areas of up to . Its ascospores are hyaline, spindle-shaped (fusiform) with between 7 and 9 septa and dimensions of 49âÂÂ52 by 13âÂÂ16 üm. No lichen products were detected in the species using thin-layer chromatography.