Astroblepus regani is a species of freshwater ray-finned fish belonging to the family Astroblepidae, the climbing catfishes. This catfish is found in South America where it is endemic to northwestern Ecuador in the Santiago-Cayapas drainage system. This species attains a maximum standard length of .
The specific name, regani, honors the ichthyologist Charles Tate Regan of the Natural History Museum (London), for his important 1904 monograph on loricariid catfishes.