Astroblepus nicefori is a species of freshwater ray-finned fish belonging to the family Astroblepidae, the climbing catfishes. This catfish is found in South America where it occurs in Sonsón in Antioquia, in the Magdalena and Cauca river basins and in the San Juan River, which drains into the Pacific. This species occurs in sandy or rocky rivers with torrential flows and abundant periphyton. A. nicefori attains a maximum standard length of .
The specific name, nicefori, honors Brother Hermano Nicéforo MarÃÂa, Museo del Instituto de La Salle, Bogotá; a Frenchman originally named Antoine Rouhaire Siauzade who became a missionary in Colombia under his monastic name, he sent a collection of Colombian freshwater fishes to Myers, including the type specimen of this one.