Aspropotamos () is a former municipality in the northwestern part of Evrytania, Greece. Since the 2011 local government reform it is part of the municipality Agrafa, of which it is a municipal unit. The municipal unit has an area of 125.954 km<sup>2</sup>. Population 1,386 (2021). The seat of the municipality was in Raptopoulo. Aetolia-Acarnania is to the west and the Karditsa regional unit to the north. Aspropotamos is located west-southwest of Karditsa, northwest of Karpenisi and north-northeast of Agrinio. The municipality was named after the Aspropòtamos river ("white river" in greek).
The municipal unit Aspropotamos is subdivided into the following communities (constituent villages in brackets):
Aspropotamos has a few schools, a lyceum (middle school), a gymnasium (secondary school) a few churches, banks, a post office.