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Asparagine synthase (glutamine-hydrolysing)

Asparagine synthase (glutamine-hydrolysing) (, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent asparagine synthetase, asparagine synthetase B, AS, AS-B) is an enzyme with systematic name L-aspartate:L-glutamine amido-ligase (AMP-forming). This enzyme catalyses the following chemical reaction

ATP + L-aspartate + L-glutamine + H<sub>2</sub>O AMP + diphosphate + L-asparagine + L-glutamate (overall reaction)
(1a) L-glutamine + H<sub>2</sub>O L-glutamate + NH<sub>3</sub>
(1b) ATP + L-aspartate + NH<sub>3</sub> AMP + diphosphate + L-asparagine

The enzyme from Escherichia coli has two active sites.

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