Argentina competed in the 2012 Summer Paralympics in London, United Kingdom, from 29 August to 9 September 2012. The country's flagbearer at the Games' opening ceremony was the swimmer Guillermo Marro.
Argentina qualified a boccia team for the BC1/BC2 team events.
Argentina qualified a team for the football 5-a-side event. The Argentine team qualified as they came second place at the 2011 Parapan American Games.
Argentina qualified a team for the football 7-a-side event. The Argentine team qualified as they came 7th in 2011 CPISRA Football 7-a-side World Championships held in Netherlands. The Iranian, Ukrainian and Brazilian teams (second, third and fourth place respectively) had already qualified for the 2012 Summer Paralympics games, allowing the Argentine team to win a spot at the Paralympics.
Three Argentine judokas competed at 2012 Summer Paralympics.
<small>Qualification Legend: FA=Final A (medal); FB=Final B (non-medal); R=Repechage</small>
Argentina qualified a boat for the 2.4MR class competition.
Argentina received 8 slots to compete at the various events at the London Aquatics Centre in London. The eight Argentine swimmers competed in various events.
Note: Ranks from qualification pools were given as an overall ranking against all other competitors.