The Arc Dome Wilderness is a protected wilderness area in the Toiyabe Range of Nye County, in the central section of the state of Nevada in the western United States. It covers an area of approximately , Nevada's largest Wilderness area. Attractions include the -long Toiyabe Crest Trail offers travelers atop the ridge of the Toiyabe Range, including within the Arc Dome Wilderness.
Wildlife in the Wilderness includes Columbia spotted frog, mule deer, sharp-shinned hawk, golden eagle, Clark's nutcracker, sagebrush sparrow, sagebrush vole, black-throated gray warbler, yellow warbler, northern goshawk, big brown bat, and Great Basin skink.
The Arc Dome Wilderness is administered by the Humboldt-Toiyabe National Forest.