Appenweier (; ) is a municipality in western Baden-Württemberg, Germany in the district of Ortenau.
Appenweier consists of the main municipal Appenweier (4,075 inhabitants), Urloffen (4,301 inhabitants), known for horseradish-growing, and Nesselried (1,383 inhabitants). The Nesselried district runs through the Wannenbach valley, while Urloffen lies north of Appenweier.