The Apopka Seaboard Air Line Railway Depot is a historic Seaboard Air Line Railroad depot in Apopka, Florida, United States. It is located at 36 East Station Street. The station was built in 1918 to serve a line originally used by the Tavares, Orlando, and Atlantic Railroad in 1885. On March 15, 1993, it was added to the U.S. National Register of Historic Places. In 2010, a proposal was made to relocate the depot.