Antonio de San Gregorio (died 1661) was a Roman Catholic prelate who was appointed as Bishop of Nueva Caceres, Philippines from 1659 to 1661.
Antonio de San Gregorio was ordained a priest in the Order of Friars Minor. On 17 November 1659, he was appointed during the papacy of Pope Alexander VII as Bishop of Nueva Caceres. He died before he was consecrated in 1661.