Anolis noblei, also known commonly as the Holguin anole, Noble's anole, and the Oriente giant anole, is a species of lizard in the family Dactyloidae. The species is endemic to Cuba. There are two recognized subspecies.
The specific name, noblei, is in honor of American herpetologist Gladwyn Kingsley Noble.
Anolis noblei is found in eastern Cuba.
The preferred natural habitat of Anolis noblei is forest, at elevations from near sea level to .
Anolis noblei is oviparous.
The following two subspecies, including the nominotypical subspecies, are recognized as being valid.