Andy Isabella (born November 18, 1996) is an American professional football wide receiver for the Ottawa Redblacks of the Canadian Football League (CFL). He played college football for the UMass Minutemen, and was selected by the Arizona Cardinals in the second round of the 2019 NFL draft.
Isabella attended Mayfield High School in Mayfield, Ohio. Isabella ran track in high school. In his senior year of high school, Isabella won the state title in the 100-meter dash, beating fellow sprinter and future Cleveland Browns cornerback Denzel Ward in a close race. He committed to the University of Massachusetts to play college football. Isabella is of Italian heritage.
Isabella played at UMass from 2015 to 2018. Initially recruited as a running back, he converted to wide receiver his sophomore year. During his career he had 231 receptions for 3,526 yards and 30 touchdowns. As a senior, he was an All-American and was a finalist for the Fred Biletnikoff Award.
In 2018, he led the country in receiving yards per game (141.5) and was named to the 2018 College Football All-America Team. Isabella was Pro Football Focus's highest rated wide receiver in college football, posting a season grade of 93.2.
Isabella declared for the 2019 NFL draft after his senior season. At the combine, Isabella ran a 4.31 second 40 yard dash, which was the third fastest time at that year's combine, tied with Ohio State wide receiver Parris Campbell.
Isabella was drafted by the Arizona Cardinals with the 62nd overall pick in the second round of the draft. The Cardinals acquired this selection in a trade that sent Josh Rosen to the Miami Dolphins. In Week 9 against the San Francisco 49ers, Isabella caught one pass for an 88-yard touchdown in the 28-25 loss. This was Isabella's first career receiving touchdown in the NFL. He finished his rookie season with nine receptions for 189 receiving yards and one receiving touchdown.
In Week 3 of the 2020 season, Isabella recorded four receptions for 47 receiving yards and two touchdowns in the 26âÂÂ23 loss to the Detroit Lions.
Isabella entered the 2021 season sixth on the Cardinals wide receiver depth chart, and only had one catch the entire season and was inactive for half the season.
On October 4, 2022, the Cardinals waived Isabella.
On October 10, 2022, Isabella signed with the practice squad of the Baltimore Ravens. On December 31, Isabella was elevated to Baltimore's active roster for their Week 17 game against the Pittsburgh Steelers. On January 2, 2023, Isabella was placed back on Baltimore's practice squad after a thigh injury in the game. On January 14, Isabella was elevated to Baltimore's active roster again for their playoff game against the Cincinnati Bengals.
Isabella signed a reserve/future contract with Baltimore on January 19, 2023. He was released by the Ravens on July 25.
On July 28, 2023, Isabella signed with the Buffalo Bills. He was waived on August 29, and re-signed to the practice squad. During the season, Isabella played in only two regular season games, and two playoff games. He signed a reserve/future contract with Buffalo on January 22, 2024. Isabella was released by the Bills on August 27.
On October 2, 2024, Isabella signed with the St. Louis Battlehawks of the United Football League (UFL).
On October 25, 2024, Isabella signed with the Pittsburgh Steelers' practice squad. He was released by the Steelers on November 5.
Isabella was re-signed by the Battlehawks on December 20, 2024. He was released by the Battlehawks on March 20, 2025.
On July 31, 2025, Isabella signed with the San Francisco 49ers. He was released by San Francisco on August 5.
On February 12, 2026, it was announced that Isabella had signed with the Ottawa Redblacks of the Canadian Football League.
Isabella signed with Athletes Untapped as a private football coach on September 8, 2025.