Phayakkhaphum Phisai (, ; , ) is a district (amphoe) of Maha Sarakham province, northeastern Thailand.
Neighboring districts are (from the north clockwise): Yang Sisurat and Na Dun of Maha Sarakham Province; Pathum Rat, and Kaset Wisai of Roi Et province; Chumphon Buri of Surin province; and Phutthaisong of Buriram province.
The district is divided into 14 sub-districts (tambons), which are further subdivided into 227 villages (mubans). Phayakkhaphum Phisai is a sub-district municipality (thesaban tambon) which covers parts of tambons Palan and Lan Sakae. There are a further 14 tambon administrative organizations (TAO).
<small>Missing numbers are tambons which now form Yang Sisurat District.</small>