Amphipolis () is a municipality in the Serres regional unit of Greece. The municipality is named after the ancient city of the same name. The seat of the municipality is Rodolivos.
The municipality Amfipoli was formed at the 2011 local government reform by the merger of the following 4 former municipalities, that became municipal units:
The municipality has an area of 411.773 km<sup>2</sup>, the municipal unit 152.088 km<sup>2</sup>. The municipal unit Amfipoli consists of the communities Amfipoli, Mesolakkia, Nea Kerdylia and Palaiokomi.