The Amite River () is a tributary of Lake Maurepas in Mississippi and Louisiana in the United States. It is about long. It starts as two forks in southwestern Mississippi and flows south through Louisiana, passing Greater Baton Rouge, to Lake Maurepas. The lower of the river is navigable. A portion of the river is diverted via the Petite Amite River and Amite Diversion Canal to the Blind River, which also flows to Lake Maurepas.
Amite could be a name derived from the Choctaw language meaning "young", although folk etymology holds it to be a corruption of the French amitié meaning "friendship".
A white bass (Morone chrysops) was caught on August 27, 2010 on the Amite River in Louisiana by angler Corey Crochet, tying an International Game Fish Association world record.