American Dad! twenty-second season premiered on Fox on February 22, 2026. It would mark the show's return to the network since September 2014, following its cancellation by TBS in March 2025. The season will feature guest appearances from Ming-Na Wen, RuPaul, Chris Pine, Bradley Whitford, Patrick Stump, Jonathan Frakes, Joe Mantegna, Wayne Newton, Mary Steenburgen and Ted Danson.
The series focuses on the eccentric upper middle class Smith family, consisting of father, husband, CIA agent, and Republican, Stan; his wife and housewife, Francine; their liberal, hippie, college-aged daughter, Hayley-Fischer; their dorky high-school-aged son, Steve; the family's unusual goldfish, Klaus; flamboyant, master of disguise alien, Roger; Jeff Fischer, Hayley Smith's stoner husband who resides with the Smith family; and Roger's ex-tumor son Rogu, who reside in a fictionalized version of Langley, Virginia.
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On March 21, 2025, TBS announced that they would not order any additional episodes of the series. It was later reported later that day that the show's original network, Fox, was in contract negotiations with the show's producer, 20th Television Animation, for a multiple season renewal. On April 2, 2025, Fox renewed American Dad for a further four seasons.
The season premiered on February 22, 2026, as part of Fox's Animation Domination block, where it airs alongside Bob's Burgers, Universal Basic Guys and Family Guy during the 2025âÂÂ26 television season.