Alis Kaplandjyan (, born December 1, 1952), is an Armenian actress.
Alis Kaplandjyan was born in Yerevan. Between 1969 and 1973 she studied at the Yerevan Fine Arts and Theater Institute. From 1973 to 1991 she was involved as an actress at Sundukyan National Academic Theater in Yerevan. During that time, she played many roles in the theater and at the same time starred in more than 10 films at Hayfilm Studio.