The Alfred Nzo District Municipality () is one of the 6 districts of the Eastern Cape province of South Africa. The seat is Mount Ayliff. The majority of its 801,344 residents speak isiXhosa. The district code is DC44.
It is named after Alfred Baphethuxolo Nzo, a former secretary-general of the African National Congress and the Minister of Foreign Affairs in Nelson Mandela's cabinet from 1994 to 1999.
The Alfred Nzo District Municipality contains the following towns: Mount Frere, Mount Ayliff, Maluti, Matatiele, Bizana and Tabankulu. It is the smallest and one of the poorest districts in the province.
Alfred Nzo is surrounded by:
The district contains the following local municipalities:
After the 2011 municipal election, Alfred Nzo District was expanded by including Mbizana Local Municipality and Ntabankulu Local Municipality, previously part of OR Tambo District Municipality.
The district is a focus area for the Umzimvubu Catchment Partnership Programme, in which Conservation South Africa participates as part of catchment-restoration work including invasive alien plant clearing and grazing-land restoration.
The following statistics are from the 2011 census.
Election results for Alfred Nzo in the South African general election, 2004.