Alfonso Rodriguez may refer to:
- Alphonsus Rodriguez (1532–1617), Jesuit brother, Roman Catholic Saint
- Alfonso RodrÃÂguez Olmedo (1598âÂÂ1628), Spanish Jesuit priest and martyr
- Alonso Rodriguez (1538âÂÂ1616), author of Ejercicio de Perfección y Virtudes Cristianas, or Practice of Perfection and Christian Virtues, sometimes translated as The Practice of Christian and Religious Perfection
- Alfonso Rodriguez Jr. (born 1953), American sentenced to death penalty for murder
- Alfonso RodrÃÂguez (director) (born 1957), Dominican actor, writer and director
- Alfonso RodrÃÂguez (gymnast) (born 1965), Spanish Olympic gymnast
- Alfonso RodrÃÂguez (Captain), 17th-century Spanish mariner and merchant
- Alfonso RodrÃÂguez (sport shooter) (born 1929), Colombian sport shooter
- Alfonso RodrÃÂguez (weightlifter) (born 1948), Puerto Rican Olympic weightlifter
- Alfonso RodrÃÂguez Salas (1939âÂÂ1994), Spanish footballer
- Alfonso RodrÃÂguez (athlete), Mexican athlete in 1977 Central American and Caribbean Championships in Athletics