Alejandro Hisis Anaya (born 16 February 1962) is a retired Chilean football defender.
Hisis played for several clubs in Latin America and Europe, including Colo-Colo, Club de Fútbol Monterrey and OFI. He is the first Chilean to play for OFI before Jaime Vera, Miguel Vargas and Felipe Gallegos.
Hisis received 41 caps for the Chile national football team, scoring twice.
Hisis has mainly served as assistant manager for clubs in his homeland, Mexico and Greece.