In enzymology, an alcohol dehydrogenase [NAD(P)<sup>+</sup>] () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are an alcohol, and either NAD<sup>+</sup> or NADP<sup>+</sup>. Its products are the corresponding aldehyde, reduced cofactor and a proton.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is alcohol:NAD(P)<sup>+</sup> oxidoreductase. Other names in common use include retinal reductase, aldehyde reductase (NADPH/NADH), and alcohol dehydrogenase [NAD(P)]. This enzyme participates in glycolysis and gluconeogenesis.