Agee Creek is a stream in Andrew County in the U.S. state of Missouri. It is a tributary of the Platte River and is long.
The stream begins in north-central Platte Township, northeast of Whitesville and travels a southwesterly course for its entire length. It crosses Route 48 about halfway along its length, and flows into the Platte River in the northern reaches of Empire Prairie Township just northeast of Happy Holler Conservation Area.