Adu Gyamfi Senior High School is a public senior high school located at Jamasi in the Sekyere East District of the Ashanti Region of Ghana.
Adu Gyamfi Senior High School was established in 1968 by Jamasi Presbyterian Church as a private institution. Initially it was known as Presbyterian Secondary Commercial School (PRESCO). The first headmaster of the school was E.K. Sarpong, with a student population of 80. The institution was absorbed into the public school system in 1974, and its name was changed to Adu Gyamfi Secondary School.