Acanthosaura nataliae is a species of lizard in the subfamily Draconinae of the family Agamidae.
The specific name, nataliae, is in honor of Russian herpetologist Natalia Borisovna Ananjeva.
Acanthosaura nataliae is found in Cambodia, Laos, and Vietnam.
The preferred natural habitat of Acanthosaura nataliae is forest, at elevations of .
Acanthosaura nataliae is arboreal and diurnal.
Acanthosaura nataliae is oviparous. Clutch size is as many as 16 eggs.